EVALUATION OF PHYTOCHEMICAL SCREENING AND ANALGESIC ACTIVITY OF AQUEOUS AND METHANOLIC EXTRACTS OF THE LEAVES OF MICROTRICHIA PEROTITII DC (ASTERACEAE) IN MICE USING HOTPLATE METHOD
Abdullahi M.N., Ilyas, N. and Ibrahim, H.
Department of Science Laboratory Technology, College of Engineering, Science and Technology, Hussaini Adamu Federal Polytechnic, Kazaure, Jigawa State. Nigeria
Abstract:
Currently, available drugs for the management of pains, fever and inflammation conditions presents with it many known adverse effects, hence the search for new drugs from plants which hitherto may harmless to humans. To this end, Microtrichia perotitii (Asteraceae) was screened for its phyto contents and analgesic properties using hotplate method with mice. The result of the preliminary phytochemical studies revealed the presence of tannins, flavonoids, saponins, alkaloids, carbohydrates and phenolics in the plant as a whole. The analgesic study showed that both the aqueous and methanolic extracts of the leaves have significant activity (P<0.05; P<0.001) as compared to morphine sulphate (10mgkg-1) used as a standard drug. Both results indicated dose-depended activity. Tannins, flavonoids and saponins have been reported to be responsible for the analgesic and anti-inflammatory activities in many medicinal plants of this family. These results may explain the use of the plant for the management of pains and its related ailments in the locality where it is very common.
